Infectious Diseases

Biography

Biography: Irina Magdalena Dumitru

Abstract

Background: Although research on the microbiome is considered an emerging sci¬ence, scientists already have made tremendous progress in understanding the microbial makeup of the microbiome and associating microbiome diver¬sity with human disease. Moreover, they are beginning to make headway in understanding how the microbiome impacts human health and disease. They are recognizing the integral role of the microbiome in human physiology, health, and disease, with microbes playing critical roles in many host metabolic pathways. The objective of the study was to assess the effectiveness of intestinal microbiome transplantation in patients diagnosed with Clostridium difficile colitis.

Material and methods: Intestinal microbiome transplant was performed in 36 patients diagnosed with Pseudomembranous colitis in Clinic of Infectious Diseases and Clinic of Gastroenterology between 01.01.2014 - 31.12.2014.

Results: Patient age ranged from 42-79 years with a median of 60.2 years, predominantly male (68%). Most patients were presented to multiple recurrences (32 cases), 4 patients did not respond to conventional therapy with metronidazole and vancomycin. All of these patients had at the time of transplantation, mild to moderate clinical forms of the disease. The evolution of the patients was favorable in all cases, the cure rate was 100%. No recurrences were reported after 10 weeks of surveillance in these patients.

Conclusion: Intestinal microbiome transplantation is a safe method with good results in the short term but also long-term prevention of recurrence in patients with pseudomembranous colitis.