Infectious and Rare Diseases

Mechanism of Resistance

Mechanism of resistance towards antimicrobials by microorganisms includes the following mechanisms of enzymatic destruction, enzymatic modification, altered target and decreased uptake. Mechanism of resistance is due to the inactivation or modification of antibiotics, an alteration in the target site of the antibiotic that reduces its binding capacity, the modification of metabolic pathways to circumvent the antibiotic effect and the reduced intracellular antibiotic accumulation by decreasing permeability and/ or increasing active efflux of the antibiotic.