Mechanism of Resistance

Mechanism of resistance towards antimicrobials by microorganisms includes the following mechanisms of enzymatic destruction, enzymatic modification, altered target and decreased uptake. Mechanism of resistance is due to the inactivation or modification of antibiotics, an alteration in the target site of the antibiotic that reduces its binding capacity, the modification of metabolic pathways to circumvent the antibiotic effect and the reduced intracellular antibiotic accumulation by decreasing permeability and/ or increasing active efflux of the antibiotic.

  • Multi drug resistance
  • Antimicrobial resistance
  • Antibiotic resistance
  • Malarial drug resistance
  • Multidrug resistant tuberculosis
  • Drug resistant tuberculosis
  • Development and spread of resistance to anti bacterial, anti fungal, anti parasitic, anti mycobacterial and anti viral agents
  • Antiviral drug resistance
  • Genetic modification
  • Animal pathogens, vaccines and functional genomics
  • Methicillin resistant staphylococcus aureus
  • Vancomycin resistant enterococci
  • Multidrug resistant pseudomonas aeruginosa and clostridium difficile
  • Extended spectrum beta lactamase producing enterobacteriaceae
  • Carbapenemase producing enterobacteriaceae

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