Elena G Fokina completed her PhD when she was 23 at Moscow Medical Dental University and postdoctoral studies in infectious diseases based 2nd Infectious Clinical Hospital in Moscow. She is a postgraduate of Central Scientific Research Institute of Epidemiology, (Moscow, Russia). The author of the invention \"Method of early prediction of the severity of diphtheria in adults\" & \"Human biochemical passport\". She has published over 60 medical articles in Russian and foreign journals. Her research interests include infectious diseases, blood coagulation disorders, biochemistry & adaptation changes. In 2014, the European scientific community awarded Elena G. Fokina the medal \"Robert Koch\".
In erysipelas we often show defects in the cutaneous barrier caused by microorganisms. In some cases, venous insufficiency (VI) may be the cause of deep venous thrombosis and delaying recovery period in erysipelas. It is important to diagnose VI at once. So we studied the native anticoagulant protein C activity for patients with erysipelas of the face and erysipelas of the legs (in some cases with the chronic venous insufficiency) in the beginning of the disease (1st week) & in the recovery period (2-3d week of illness).
rnPatients were treated at the Infectious Diseases Hospital № 2 (Moscow). A total of 60 people diagnosed with «erysipelas of the face» (n = 24) and «lower limb erysipelas» (n = 36). A lighter form - erythematous EF was 52% of cases. More severe EL (hemorrhagic and erythematous-bullous-hemorrhagic) forms were in 71% of cases. The average hospital stay with EL was 11.9 + 4.1 days, with EF - 8.4 + 1.6 days. We observed positive dynamics of protein C in patients with erysipelas of the face & legs. However, in patients with erysipelas of the legs with chronic venous insufficiency it remained unchanged, despite the regression of clinical symptoms of erysipelas. When protein C in the normal range (control - 97.3 + 0.38%) the possibility for a quick recovery higher (OR = 2.89 [0.15, 55]) comparing with EL with VI. So, protein C can be used as an indicator of the risk of venous thrombosis and as a favorable prognostic indicator of erysipelas.
Abdelwahid Saeed Ali (PhD) is currently serving as a professor of virology and medical biotechnology in the College of Medicine, King Khalid University (KKU) in Saudi Arabia. He obtained his PhD in virology form Putra University in Malaysia in 2000 and had a post-doctoral fellowship in medical biotechnology at Duke University Medical Center (DUMC), in Duke University in North Carolina, USA (2005- 2007). At Duke he did some research work dealing with the molecular factors regulating the mitochondrial biogenesis during sepsis in mammalian cells. As a result of that of research work, he published his research data in most reputable journals in USA. He passed all his academic career started as a teaching assistant moving through lecturer, assistant professor, associate professor till he become a full professor in 2010. Through that academic marsh, he was actively involved in teaching, research leadership, graduate students supervision, institution and community service.
Human metapneumovirus (hMPV) is classified in the metapnuemovirus genus, Pneumovirinae subfamily of the Paramyxoviridae family. It was isolated for the first time in 2001 in the Netherlands and then reported in many parts of the world with seasonal distribution. It may be the second most common cause (after the respiratory syncytial virus, RSV) of pediatric lower respiratory illness. However, hMPV can also cause upper respiratory tract infections across all age groups. Compared with RSV, infection with hMPV occurs in slightly older children and to produce less severe disease. Co-infection with both viruses can also occur and associated with worse disease. hMPV were known to account for approximately 10% of respiratory tract infections worldwide. The transmission occurs by contact with contaminated secretions, via droplet, aerosol, or fomite vectors. Infection with hMPV results in symptoms of bronchiolitis and pneumonia. Laboratory testing for identification of hMPV include: PCR, ELISA and immunofluorescence. In the present study, the role of hMPV in LRT infections in children in Aseer area (Southwest Saudi Arabia) was investigated for the first time. An amount of 98 samples of respiratory secretions in swabs were collected from patients who attended the pediatric clinics with respiratory problems at Aseer Central Hospital. Samples were collected from patients in both genders, different ages and with different geographical and social backgrounds. Direct Fluorescent Antibody (DFA) techniques using the commercial kit was employed to determine the presence of the virus antigens in these specimens. The technique was made exactly as described by the direct immunoflouresnce Kit manufacturers with some modifications. 9 samples out of 98 (9.18%)collected were found positive to the virus. Positive cases includes patients from both genders and from 6 out of 7 geographical distributions tested. In conclusion, hMPV was reported for the first time to be incriminated in the causation of lower respiratory tract infections in the study area.