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Michael Brady

Michael Brady

Nationwide Children’s Hospital, USA

Title: Maternal immunizations: Protects mother, fetus and newborn infant

Biography

Biography: Michael Brady

Abstract

Many infectious diseases can adversely affect the health of pregnant women; adversely impact the fetus directly during gestation and cause infectious illnesses in newborn infants who are too young to receive benefit from available vaccines. Globally, 10-50% of still births are due to maternal/fetal infections; 600,000-800,000- neonatal deaths are due to infections. Maternal immunizations with vaccines targeting influenza, pertussis and tetanus have already provided improved maternal health during pregnancy, fewer adverse fatal fetal events and reduced illness in young infants. Infections in young infants frequently result in illness and the need for medical care; while some result in morbidity and even mortality. Some of these infections are due to vaccine-preventable conditions which are acquired at an age prior to completion of an effective vaccine series, e.g. influenza, meningococcal group B, pertussis. Other infections are caused by infections for which there is no currently available vaccine, e.g. group B streptococcus and respiratory syncytial virus (RSV). Utilizing vaccines more effectively during pregnancy could result in better health outcomes for the mother, her off-spring or both. Future candidates for maternal immunizations include: Group B streptococcus vaccine, respiratory syncytial virus vaccine, meningococcal group B vaccine, meningococcal conjugate vaccine (MenACWY) and pneumococcal conjugate vaccine. Considerations that will impact successful utilization of a maternal immunization strategy include: Vaccine safety during pregnancy: Mother and fetus, vaccine efficacy for mother, fetus and infant, increasing capacity and acceptance of vaccine administration by obstetric providers and cost.

Recent Publications

  1. Omer SB (2017) Maternal Immunization. NEJM 2017. 374: 1256-67.
  1. Edwards KN (2017) Ensuring vaccine safety in pregnant women. NEJM 2017. 376: 1280-1282.
  1. Kourtis A P, Read J S, Jamieson D J (2014) Pregnancy and Infection. N Engl J Med 2014. 370: 2211-2218.
  1. Munoz FM, Bond NH, Maccato M, et al. (2014) Safety and immunogenicity of tetanus diphtheria and a cellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a randomized clinical trial. JAMA 2014. 311: 1760-1769.
  1. Tapia M D, Sow S O, Tamboura B, et al. (2016) Maternal immunization with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial. Lancet Infect Dis 2016. 16: 1026-1035.