6. Rare Diseases in Cancer and Aging

Rare cancers tend to be caused by simple genetic mutations, and common cancers tend to be caused by a complex set of genetic and epigenetic aberrations that continually increase in number as the tumor develops. All cancers that can be cured when in an advanced clinical stage are rare cancers. Rare cancer syndromes typically produce various types of cancers, including rare cancers and common cancers.

Aging is a collection of degenerative changes that occur in organisms that lack the ability to perpetually regenerate. Age is a major risk factor for most common neurodegenerative diseases. Dementia becomes more common with age. The spectrum includes mild cognitive impairment, Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. Rare diseases provide much insight into the cellular processes that hasten the aging process.

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